By Togas Tulandi, Morrie Gelfand
The topic of androgen therapy in reproductive elderly men and women is attracting expanding curiosity from experts in copy drugs, endocrinology and first care prone, in addition to from sufferers and the media.
The first booklet to hide androgen alternative in males and ladies, Androgens and Reproductive Aging addresses the emotive issues of reproductive getting older, the menopause and using androgen vitamins to mitigate their results.
Edited through major experts in reproductive medication and infertility, and boasting an all-star solid of authors, this entire textual content covers:
* androgen construction within the fit female and male
* the decline of androgen construction in the course of getting older, with the linked results on physique composition and libido
* the advantages and power side-effects of androgen substitute therapy.
Ideal for a variety of clinicians and scientists attracted to reproductive getting older, the menopause, hormone alternative and androgen treatment, in addition to obstetricians, gynecologists and relatives practitioners, this specified textual content is a hugely very important addition to literature within the area.
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Additional resources for Androgens and Reproductive Aging
Intracycle variation of androgen production may also be seen as a result of aging. Mushayandebvu et al. 4). 63 Couzinet et al. refuted this view in 2001 with a small study of adrenally compromised women either naturally postmenopausal or after oophorectomy and compared them with normal, postmenopausal, or oophorectomized controls. In their analysis, very low to undetectable levels of total testosterone, free testosterone, androstenedione, and DHEA were seen in the adrenal insufficiency cohort regardless of the presence or absence of ovaries.
13 Recent studies have suggested that different genes may be activated by different ligands and that this may be reconciled by the presence of cellspecific and limiting transcription factors and coactivators. In addition, the local concentration of the androgen hormone depends on the expression and activity of steroid-converting enzymes such as dehydrogenases and reductases; the latter of which play important roles in the peripheral conversion of androgens to active or inactive metabolites. Furthermore, the tissue and cell-specific expression of different coactivators or corepressors in different target cells plays an important role in specific gene expression by androgens in various target tissues.
Inhibin B production is not provoked by LH or hCG in the male testis thus it serves as a measure of testicular reserve, similar to ovarian reserve in women. However, unlike women, this is less tightly linked to fertility potential. 33 Testicular volume can act as a surrogate for tubular volume, and thus spermatogenesis. 34 Thus the drop in testosterone observed seems less a function of Sertoli/ Leydig cell number but more of a function or responsiveness to LH and FSH. Luteinizing hormone Central defects in the hypothalamic–pituitary axis have been proposed as the cause of hormonal profiles in men.