By Richard Bertram, Arthur Sherman
Insulin-secreting β-cells, positioned in the pancreatic islets of Langerhans, are excitable cells that produce ordinary bursts of motion potentials whilst motivated via glucose. the program has been the point of interest of mathematical research for 2 a long time, spawning an array of mathematical types. lately, a brand new classification of types has been brought referred to as 'phantom bursters' [Bertram et al. (2000) Biophys. J. seventy nine, 2880-2892], which money owed for the big variety of burst frequencies exhibited via islets through the interplay of a couple of gradual procedure. the following, we describe one implementation of the phantom bursting mechanism during which intracellular Ca2+ controls the oscillations via either direct and oblique unfavorable suggestions pathways. We express how the version dynamics could be understood via an extension of the fast/slow research that's commonly hired for bursting oscillations. From this angle, the version uses a number of levels of freedom to generate the whole variety of bursting oscillations exhibited through β-cells. The version additionally bills for a variety of experimental phenomena, together with the ever-present triphasic reaction to the step elevation of glucose and responses to perturbations of inner Ca2+ shops. even though it isn't almost immediately an entire version of all β-cell homes, it demonstrates the layout rules that we count on will underlie destiny growth in β-cell modeling.
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Additional resources for A calcium-based phantom bursting model for pancreatic islets
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