By John S. Bradley, John D. Nelson et al. (eds.)
New twenty first Edition! This bestselling and universal source on pediatric antimicrobial therapy presents quick entry to trustworthy, up to the moment strategies for remedy of all infectious ailments in teenagers.
Practical, evidence-based strategies from the specialists in antimicrobial therapy
- Developed through wonderful editorial board
- Designed if you happen to look after teenagers and are confronted with judgements each day
- New at-a-glance tables of bacterial and fungal pathogen susceptibilities to general antimicrobials
- New info on neonatal developmental pharmacology
- Includes remedy of parasitic infections and tropical medicine
- Updated checks in regards to the energy of the advice and the extent of facts for remedy concepts for significant infections
- Anti-infective drug directory, whole with formulations and dosages
- Antibiotic remedy for overweight children
- Antimicrobial prophylaxis/prevention of symptomatic infection
- Maximal grownup dosages and better dosages of a few antimicrobials established in children
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Extra info for 2015 Nelson's Pediatric Antimicrobial Therapy
VANCOMYCINa 40 — Chapter 5. Antimicrobial Therapy for Newborns E. Use of Antimicrobials During Pregnancy or Breastfeeding Antimicrobial Therapy for Newborns The use of antimicrobials during pregnancy should be balanced by the risk of fetal toxicity, including anatomical anomalies. A number of factors determine the degree of transfer of antibiotics across the placenta: lipid solubility, degree of ionization, molecular weight, protein binding, placental maturation, and placental and fetal blood flow.
Please check your local susceptibility data for S aureus before using clindamycin for empiric therapy. For MSSA, oxacillin/nafcillin are considered equivalent agents. The first pediatric-specific PIDS/IDSA guidelines for bacterial osteomyelitis and bacterial arthritis are currently being written. 41 See Chapter 5. – Infants (S aureus, including CA-MRSA; group A streptococcus; Kingella kingae; in unimmunized or immunocompromised children: pneumococcus, H influenzae type b) Empiric therapy: clindamycin (to cover CA-MRSA unless clindamycin resistance locally is >10%, then use vancomycin).
Htm. Evaluation and treatment do not depend on mother’s HIV status. Obtain follow-up serology every 2–3 mo until nontreponemal test nonreactive or decreased 4-fold. If CSF positive, repeat spinal tap with CSF VDRL at 6 mo, and if abnormal, re-treat. – Proven or highly probable disease: (1) abnormal physical examination; (2) serum quantitative nontreponemal serologic titer 4-fold higher than mother’s titer; or (3) positive dark field or fluorescent antibody test of body fluid(s) Aqueous penicillin G 50,000 U/kg/dose q12h (day of life 1–7), q8h (>7 days) IV OR procaine penicillin G 50,000 U/kg IM q24h for 10 days (AII) Evaluation to determine type and duration of therapy: CSF analysis (VDRL, cell count, protein), CBC and platelet count.